24 noticias erasmus polonia mar

Within the framework of a ERASMUS+ program, Jolanta Jaśkowska and Kamila Tomera from Cracow University of Technology, Poland, will be visiting CQM and give two lectures on organic catalysis and phase transfer catalysis. They will join Ruilong Sheng, Senior Researcher of CQM, for a two-day seminar, scheduled as follows:

• 05 March 2024 - 14h00-16h00

“Green synthesis of bioactive compounds under phase transfer catalysis (PTC) conditions”
by Jolanta Jaśkowska, PhD - Krakow University of Technology, Poland

ABSTRACT
In recent years, research efforts have focused on the search for methods of synthesis of organic compounds that are characterized by a simplicity of the individual stages of the process and the use of readily available and safe reagents while maintaining high selectivity and efficiency. Moreover, a very important aspect is to limit the amount of harmful and environmentally toxic byproducts and waste, especially in larger-scale reactions. Therefore, "green chemistry" focused on the designing of products and processes that minimize or eliminate the use and generation of hazardous substances is playing an increasingly important role in synthesis processes. Phase transfer catalysis (PTC) is largely in line with the principles of green chemistry, because it allows to reduce toxic reagents and conduct the process in milder conditions, e.g. room temperature, atmospheric pressure. In addition, by conducting reactions with the use of PTC catalysts and in the presence of microwave radiation or ultrasounds, the process time can be shortened many times, and in many cases they also have a positive effect on selectivity. The research we have been conducting for several years has shown that by conducting reactions using PTC catalysts in the presence of microwave radiation or ultrasonic conditions, bioactive compounds with a very high purity of >95% can be successfully obtained in a short time of just a few minutes.

ABOUT LECTURER
PhD Jolanta Jaśkowska, Research and teaching assistant professor at the Institute of Organic Chemistry and Technology, Faculty of Chemical Engineering and Technology, Krakow University of Technology. In her scientific work, she conducts research which aim is to discover new bioactive compounds, particularly ligands of serotonin receptors. Moreover, she develops methods of synthesis in solvent-free conditions as a part of “green chemistry”. She has both theoretical and practical knowledge of managing research projects. Apart from participating in scientific projects, she has led many projects in cooperation with companies in pharmaceutical, cosmetic, and food industry. She is a co-author of 40 scientific publications and 13 granted patents. She has a documented knowledge of commercializing scientific research moreover she participated in numerous scientific internships, including: Stanford University (USA), Rutgers University (USA), National Technical University of Athens (Greece).


• 05 March 2024 - 16h20-17h20

“Click Chemistry in the synthesis of Bioactive Molecules, Functional Glycopolymers and Biomaterials”
by Ruilong Sheng, PhD - CQM - Madeira Chemistry Research Centre, Portugal

ABSTRACT
Click chemistry has been proven to be highly efficient due to its mild reaction conditions, high efficiency, good adaptivity to functional groups, and easy purification of products. The typical “click” chemistry involved Cu (I)-catalyzed azide-alkyne [3 + 2] cycloaddition (CuAAC), strain-promoted cycloaddition of alkynes and azides (SPAAC), thiol-involved click reactions, Diels-Alder [4+2]-type click reaction, oxime formation and so on. In this short lecture, combining our past research works, we will briefly introduce the progress of “click” reactions and discuss the application of Click chemistry and reactions in the synthesis of bioactive molecules, glycopolymers and glycopolypeptides, as well as functional biomaterials.

ABOUT LECTURER
Dr. Ruilong Sheng, received his B.Sc. (Biochemistry) in 2002 from South-central University for Nationalities, China, and Ph.D. (Organic chemistry) in 2008 from the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences (CAS). He conducted his postdoctoral research (2009-2011) on organic polymer chemistry and biomaterials and then worked as a research professor at Shanghai Institute of Organic Chemistry, CAS from (2011-2017). Then he worked at Université de Montréal and McGill University (2015-2017), Canada, as an invited scientist/professor. After 2017, he joined CQM-Centro de Química da Madeira at Universidade da Madeira, Portugal as a Senior/Leading researcher (R4) and group leader. His research interests include organic chemistry, macromolecular and polymer chemistry, natural products, supramolecular chemistry, photochemistry and fluorescent probes, biomaterials, and nanobiotechnology.


• 06 March 2024 - 14h00-16h00

“Catalytic dehydrogenation of paraffins – study of dehydrogenation of propane in the presence of CO2 over VOx/SBA -15. Heterogeneous catalysts – methods of preparation”
by Kamila Zeńczak-Tomera, PhD - Krakow University of Technology, Poland

ABSTRACT
Propene is a significant chemical feedstock for production of various valuable building-blocks for polymers production and chemical intermediates, such as propylene oxide, acrylonitrile, acrylic acid or cumene. The main sources of propene are steam cracking and fluid catalytic cracking. Additional sources are on-purpose technologies such as MTO and MTP processes (methanol to olefins/propene), olefin metathesis and propane dehydrogenation (PDH).The meaning of on-purpose technologies rising due to propylene gap. The recent years and the forecasts of propene demand show still increasing tendency. Among processes previously mentioned, PDH is very beneficial because it allows to convert low-value paraffin to value-added olefin with high selectivity. However, commercialized non-oxidative pathway has some limitations like high temperature need for achieving economically reasonable per-puss conversion of propane or cyclic catalyst regeneration. The dehydrogenation of propane with CO2 has been studied as an alternative technology for non-oxidative dehydrogenation of propane. In the new process, propene is obtained with higher yield than in the traditional one. This promoting effect of CO2 on the yield of propene is explained by its participation in direct oxidation of propane to propene, hydrogen consumption by reverse water-gas shift reaction and coke gasification.

ABOUT LECTURER
PhD Kamila Zeńczak-Tomera, Teaching assistant at the Institute of Organic Chemistry and Technology, Faculty of Chemical Engineering and Technology, Cracow University of Technology. The subject of scientific research of Dr. Eng. Kamila Zeńczak-Tomera is related to the management of carbon dioxide in chemical syntheses. It is extremely interesting from both chemical and ecological point of view. Moreover, she is interested in preparation heterogeneous catalysts based on nanomaterials. Her results were presented at numerous prestigious scientific conferences and papers. Dr. Eng. K. Zeńczak-Tomera is an ambitious person, constantly improving her skills (participation in training, summer schools, postgraduate studies, internships - including teaching - Erasmus + or research projects). Mrs. Dr. Eng. Kamila Zeńczak-Tomera was a member of the Faculty Council (elected) in the 2012-16 and 2016-2020. She is involved in activities promoting Polish science and the Faculty e.g. open days, Science Festival in Cracow or Małopolska Night of Scientists.

GENERAL INFORMATION
Date: 05-06 March 2024
Schedule: from 14h00 (PT, Lisbon time)
Venue: University of Madeira, Campus of Penteada, Conference room 0.57.
Fee: Free admittance.

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24 noticias est verao

Encontra-se aberta a 1ª fase de manifestações de interesse aos “Estágios de Verão no CQM 2024”.

O Centro de Química da Madeira (CQM) recebe todos os anos, durante o período de Verão, estudantes universitários do 1º Ciclo (2º e 3º anos) e detentores de diploma (do 1º ou 2º Ciclos) para a realização de estágios de curta duração, a desenvolver no âmbito dos programas regionais para ocupação de jovens nas férias.

O período de manifestação de interesse acontece de 01 a 25 de fevereiro de 2024, através do preenchimento do formulário disponível aqui. Neste formulário, ser-te-á pedido para selecionares até duas áreas de investigação onde, preferencialmente, gostavas de desenvolver o teu estágio de verão no CQM, e para submeteres o teu Currículo vitae para fins de avaliação. 

Este ano, o CQM vai disponibilizar várias temáticas de estudo que visam proporcionar uma experiência enriquecedora numa das duas grandes áreas de investigação de investigação do CQM – Materiais e Produtos Naturais – sendo elas, especificamente:

- Biomateriais
- Bioquímica
- Electroquímica
- Química Alimentar
Química Analítica
- Química Bioinorgânica
Química Computacional
- Química Física 
- Química Orgânica

Os interessados selecionados serão contactados pelo CQM para formalizarem a candidatura junto das entidades regionais que promovem os programas de Estágios de Verão para Universitários e Ingress@.

Nota: Estes estágios no CQM não substituem quaisquer disciplinas curriculares realizadas em contexto académico.

A tua oportunidade está aqui, no CQM!

23 noticias last minute xshi seminar

Next 14th and 15th December, 2023, the Madeira Chemistry Research Centre (CQM) will organize two seminars (by Zoom) with Professor Xiangyang Shi (CQM Senior Researcher and Vice Dean of the College of Biological Science and Medical Engineering, Donghua University, China):

Thursday, Dec 14, 2023 - 09:00 Lisbon time
Dendrimers for Imaging applications" - By Zoom

Friday, Dec 15, 2023 - 09:00 Lisbon time
"Functional nanogel design for tumor theranostics” - By Zoom

ABOUT XIANGYANG SHI
Xiangyang Shi is currently a professor and serves as the Vice Dean of the College of Biological Science and Medical Engineering, Donghua University.
Prof. Xiangyang Shi graduated with B.Sc. (chemistry, Henan Normal University, Xinxiang), M.E. (applied chemistry, Beijing Institute of Technology, Beijing), and Ph.D. (organic chemistry, Institute of Photographic Chemistry, the Chinese Academy of Sciences, Beijing) in 1992, 1995 and 1998, respectively. He worked as a Postdoctoral Fellow in Tsinghua University (1998-2000, Beijing) and Max-Planck Institute of Colloids and Interfaces (2000-2001, Potsdam, Germany). He then moved to California State University, Los Angeles (2001-2002) as a visiting scholar. From 2002-2008, he worked as a Research Fellow, Research Associate II, Research Investigator, and Research Assistant Professor at the University of Michigan, Ann Arbor. He then became a professor of special appointment both in Donghua University and in Shanghai Institutions of High Learning (Eastern Scholar) since 2008. Since 2010 he is also appointed as an “Invited Chair in Nanotechnology” at University of Madeira, Portugal.
Prof. Shi has authored or coauthored 487 SCI-indexed peer-reviewed journal articles with an H-index of 84 and 342 technical conference abstracts or proceeding papers, along with 17 invited book chapters and 128 approved patents. His current research interests are focused on the development of organic/inorganic hybrid nanoplatforms and microfluidic platforms for sensing, imaging, and theranostic applications, in particular for precision imaging and therapy of cancer and inflammatory diseases.

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24 noticias seminario cost action

Registration is open for the seminar "Signaling concepts and perspectives of Adhesion GPCR research", to be held at CQM, on 09 February 2024. This lecture will be given by Ines Liebscher (University of Leipzig, Germany) and Simone Prömel (Heinrich Heine University of Düsseldorf, Germany), under the aim of the COST Action "Adher´n Rise.

GENERAL INFORMATION
Date: 09 February 2024
Schedule: 09h30 (PT, Lisbon time)
Venue: University of Madeira, Campus of Penteada, Conference room 0.57.
Fee: Free admittance.

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23 noticias seminar serge

Next 13th December, 2023, the Madeira Chemistry Research Centre (CQM) will organize the seminar "Present drug-likeness filters in medicinal chemistry during the hit, lead, and clinical candidate optimization process: An analysis", with Professor Serge Mignani, to be held at the University of Madeira.

ABSTRACT
During the past decade, decreasing the attrition rate of drug development candidates reaching the market has become one of the major challenges in pharmaceutical research and drug development (R&D). To facilitate the decision-making process, and to increase the probability of rapidly finding and developing high-quality compounds, numerous multiparametric guidelines, also known as rules and ligand metrics, have been developed including a quantitative estimate of drug-likeness (QED). However, what are the ‘best’ descriptors and how far can we simplify these drug-likeness prediction tools based on molecular properties in terms of the numerous, complex properties that they relate to? In this presentation, we will survey and analyze the current and recent hit and lead physicochemical optimization parameters, including ligand efficiency metrics for drug-likeness indexes, and analyze their drug-likeness properties. We will also present and discuss the ‘best’ descriptors for monitoring physicochemical parameters during optimization and also how far we can simplify these drug-likeness prediction tools during the multiparametric optimization process (MOP) for determining the potency and safety drug profiles of compounds in humans. Finally, we propose a simple strategy for applying rules and metrics in the drug discovery process to aid the design of compounds to help us prioritize the best drug-like compounds and predict ADME behavior in humans.

Professor Serge Mignani, from the Centre d’Etudes et de Recherche sur le Médicament de Normandie and the Argobio Studio (France) was, for more than 40 years, researcher in one of the biggest pharmaceutical industries, Rhône-Poulenc, currently named Sanofi, where he served as director of the Medical Chemistry Department. He is now a consultant for several big and medium pharmaceutical industries (France and USA) and Institutes (France, China, Portugal, and India). He collaborates with the University of Madeira since 2013 and is officially a CQM researcher since 2017, being responsible for the Medicinal Chemistry area and nanomedicine translation activities.

GENERAL INFORMATION
Date: 13 December 2023
Schedule: 09h00-10h00 (PT, Lisbon time)
Venue: University of Madeira, Campus of Penteada, Classroom 29.
Fee: Free admittance.

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