Dendrimers, as well-defined and highly branched macromolecules, offer significant potential in drug delivery due to their multifunctionality and specific architecture. Polyamidoamine (PAMAM) dendrimers, comprising a central core, radially extending repeating units, and terminal functional groups, are particularly notable. The interaction between oppositely charged dendrimers and surfactants results in the formation of various materials, including nanoparticles for drug delivery, vesicles for cell models, and corrosion-resistant thin films. Dendrimers are promising candidates for designing colloidal drug delivery systems through interactions with anionic surfactants. This study aims to explore the physicochemical properties of colloidal PAMAM/fatty acid complex systems and assess their suitability for sustained drug release. These systems could be employed for ocular, pulmonary, or intravenous delivery, or to enhance absorption through the gastrointestinal tract, ultimately improving therapeutic efficacy. The research focuses on optimizing PAMAM/fatty acid complexes as vectors, exemplifying efforts in pharmaceutical research to develop dendrimer-based supramolecular delivery systems. The optimized formulation of PAMAM dendrimer and fatty acid nanoparticles was prepared and evaluated for drug entrapment, in-vitro release, and in-vivo studies, demonstrating the potential for controlled delivery of bioactive agents. The formation of PAMAM dendrimer-fatty acid complexes involves the interaction between the dendrimer and fatty acid molecules. This interaction may be driven by various forces, such as hydrogen bonding, hydrophobic interactions, and electrostatic interactions. 

PAMAM dendrimer-fatty acid complexes represent a versatile and promising platform for the delivery of bioactive compounds. Their ability to enhance solubility, stability, and targeted delivery of therapeutic agents makes them attractive candidates for a wide range of biomedical applications. Continued research and development in this field hold the potential to significantly advance drug delivery technologies and improve patient outcomes.