Reactive oxygen species (ROS), as a kind of metabolite in the biological respiratory chain, play an important role in maintaining the normal physiological functions of organisms. However, the excessive production of ROS is considered to be a fatal factor leading to aging, degenerative diseases, and malignant tumors. Therefore, the expression level of a specific kind of ROS is considered as a biomarker for the related diseases. In addition, due to their high chemical reactivity, ROS may also be used as an activator of prodrugs or drug delivery systems for the treatment of corresponding diseases. The activated prodrug strategy is one of the effective ways to reduce the side effects of the drugs. However, the lack of efficient activation platforms severely limits the application of the prodrug strategy. To solve this problem, we developed a series of ROS triggered release platforms by optimizing the structure of our reported ROS probes [1]. By using these platforms, a series of responsive prodrugs and nano systems that could be activated by high level of ROS in desease site were constructed [2-3]. This strategy could integrate detection, imaging and therapeutic functions, and significantly improved the enrichment efficiency in desease region, simultaneously reduced the toxic side effects of drugs.

 Acknowledgments: The authors gratefully acknowledge the financial support from NNSFC (22371038, 22177019).

References
 [1] (a) Wei, P.; Liu, L.; Wen, Y.; Zhao, G.; Xue, F.; Yuan, W.; Li, R.; Zhong, Y.; Zhang, M.; Yi, T. Angew. Chem. Int. Ed. 2019, 58, 4547. (b) Liu, L.; Jiang, L.; Yuan, W.; Liu, Z.; Liu, D.; Wei, P.; Zhang, X.; Yi T. ACS Sens. 2020, 5, 2457. (c) Wei, P.; Liu, L.; Y. Wei, Yang, J.; Li, R.; Yi, T. Sci China Chem, 2020, 63, 1153. 
[2] (a) Liu, L.; Liu, F.; Liu, D.; Yuan, W.; Zhang, M.; Wei, P.; Yi, T. Angew. Chem. Int. Ed. 2022, 61: e202116807. (b) Liu, F.; Liu, L.; Liu, D.; Wei, P.; Feng W.; Yi, T. Chem. Sci. 2022, 13: 10815. (a) Liu, D.; Liu, L.; Liu, F.; Zhang, M.; Wei, P.; Yi, T. Adv. Sci. 2021, 2100074. 
[3] (a) Wang, C.; Zhu, J.; Wang, S.; Zhao, L.; Wei, P.; Yi, T. Adv. Mater. 2024, 2309789. (b) Wang, C.; Wang, R.; Zhao, L.; Wang, S.; Liu, Y.; Zhao, J.; Dong, Y.; Liu, L.; Wei, P.; Wu, Z.-Y.; Yi, T. Redox Biology 2024, 70, 103076; (c) Wang, B.; Lu, Z.; Song, M.; He, X.; Hu, Z.; Liang, H.; Lu, H.; Chen, Q.; Liang, B.; Yi, T.; Wei, P.; Jiang, L.; Dong, J. Adv. Sci. 2024, 2303981.