SitCon (SITe CONservation) is a tool designed to explore conservation of functionally important sites in a series of hypothetically homologous candidate protein structures, and predict the function of a test protein whose aminoacid sequence is used as input. SitCon can also predict the presence of metal containing heterogroups and allows the visual comparison of binding site conservation between candidate and test proteins. This makes the tool useful also for analysis of proteins with known function.The algorithm used is not based on specific protein signatures, it works well even with very low homology candidate molecules thus allowing the detection of overlooked relationships between proteins.
- Science & Society
- News Room